Overview

Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL

Status:
Unknown status
Trial end date:
2020-08-30
Target enrollment:
Participant gender:
Summary
ETP-ALL is a recently recognized high-risk subgroup and the optimal therapeutic approaches are poorly characterized. Based on the pediatric-inspired, PEG-L-asparaginase-intensified and MRD-directed PDT-ALL-2016 protocol, this open-label, one-arm, multi-site trial is aimed to evaluate the safety and effect of a novel oral histone deacetylase inhibitor chidamide for adult ETP-ALL/LBL in CHINA.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Nanfang Hospital of Southern Medical University
Treatments:
6-Mercaptopurine
BB 1101
Cyclophosphamide
Cytarabine
Dexamethasone
Dexamethasone acetate
Doxorubicin
Etoposide
Etoposide phosphate
Histone Deacetylase Inhibitors
Idarubicin
Liposomal doxorubicin
Mercaptopurine
Methotrexate
Pegaspargase
Vincristine