Predicting Ovarian Response in Artificial Insemination With Low Stimulation

• Status: Unknown status
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This large prospective multi-center cohort study aims to identify patient's characteristics that significantly influence ovarian response to mild stimulation with a fixed dose of 75 IU recombinant FSH.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Isala
• Collaborator: Merck Serono International SA
• Treatments: Follicle Stimulating Hormone; Hormones

Criteria

Inclusion Criteria:

• couples with unexplained or mild male subfertility (1-3) and a spontaneous chance of conception below 40% (Hunault score).

• Unexplained subfertility including minimal to mild endometriosis (AFS grade 1 or 2) is defined as the failure to conceive after at least one year of unprotected intercourse whereas the standard fertility work-up was unable to detect any factors that might influence fertility negatively.

• semen analysis should be normal according to the WHO guidelines (8),

• ovulation should be documented (by BBT charts, ovulation detection by ultrasound or normal luteal progesterone values),

• tubal patency should be confirmed (HSG, laparoscopy or fertiloscopy) and when a postcoital test was performed a cervical factor should have been excluded.

• Mild male subfertility is defined as abnormal semen parameters according to the WHO (8) but an average total motile sperm account before processing of at least 10 million.

Exclusion Criteria:

• Hunault score ≥ 40%

• Endometriosis AFS grade 3 or 4

• Contra-indications for the use of gonadotrophins (cysts larger than 2 cm, allergy for gonadotrophins)

• Total motile sperm count after sperm processing below 1 million

• Women aged younger than eighteen years or older than 45 years.

• Previous treatment with COH/IUI for treating current subfertility

• Unable to speak or read the Dutch language