Predictors of Aspirin Failure in Preeclampsia Prevention
Status:
Not yet recruiting
Trial end date:
2024-11-01
Target enrollment:
Participant gender:
Summary
Hypertensive disorders of pregnancy (including preeclampsia) are among the leading causes of
pregnancy complications and maternal deaths worldwide. They also increase the risks to the
babies. Numerous interventions have been suggested in order to reduce the rate of
preeclampsia. Low-dose aspirin is the most beneficial prophylactic approach in this regard.
Nevertheless, aspirin failure is not uncommon. The genetic, laboratory, and clinical factors
associated with low-dose aspirin failure in the prevention of preeclampsia are largely
unknown. The presence of a genetic variant in PAR4 receptor expressed on platelets, is
associated with increased platelet function and possibly with aspirin failure.