Predictors of the Outcome of Late Life Depression

• Status: Unknown status
• Trial end date: 2019-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Predictors of response to pharmacological treatment of major depressive disorder will be investigated. One hundred and twenty patients will be included in a naturalistic clinical trial. Psychopathology, personality traits, cognitive performance, brain structural changes and genetic polymorphisms will be evaluated. Patients will be followed for 18 months with a pharmacological treatment algorithm and will be evaluated monthly until 6th month and every 3 months, up to 18 months. Psychoeducation will be offered to patients who did not remit until 3 months of pharmacological tretment.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo General Hospital
• Collaborator: Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Antidepressive Agents

Criteria

Inclusion Criteria:

• 60 years old

• Major depression (DSMIV-TR)

• Evaluated with MINI

• Willing to participate.

Exclusion Criteria:

• Less than 60 years old

• Dementia syndrome

• Delirium or other organic mental disorders

• Alcohol/drug dependence

• Anxiety disorders, or other psychiatric disorders, and not willing (or not able) to participate