Prednisone for Decompensated Congestive Heart Failure

• Status: Suspended
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

We designed this, randomized, double-blind, placebo-controlled trial to determine the clinical efficacy of chronic administration of prednisone on renal function and clinical status when added to standard care.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hebei Medical University
• Treatments: Prednisone

Criteria

Inclusion Criteria:

• Hospitalized with primary diagnosis of CHF

• Patients with normal cortical function

• LVEF <40%

• Significant fluid overload, defined as ≥ 2 of the following

• Enlarged liver or ascites

• Peripheral or sacral edema ( ≥ 2+)

• Jugular venous distention ≥ 10 cm

• Pulmonary rales, pleural effusion on chest x-ray or orthopnea

Exclusion Criteria:

• Severe stenotic valvular disease

• Serum creatinine > 4 mg/dl

• Patient refusal

• Any signs of infection or any condition that would contraindicate an glucocorticoids use

• Poor controlled hypertension

• Poor controlled diabetes mellitus

• Active myocarditis

• Malignancy or other terminal illness