Preemptive Analgesic Efficacy of Parecoxib for Reducing Postoperative Pain in Gynecological Surgery

• Status: Recruiting
• Trial end date: 2024-06-27
• Target enrollment: 0
• Participant gender: Female

Summary

The research is to test the preemptive analgesic efficacy of Parecoxib drug in gynecological surgery by comparing Parecoxib drug and NSS administration 15 min before starting the surgery which the result of postoperative pain score is interpret by visual analog scale index

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rajavithi Hospital
• Treatments: Parecoxib

Criteria

Inclusion Criteria:

• Female patients age between 18-70 year-old, who participate in explor lap gynecological surgery (Hysterectomy, Adnexal surgery and surgical stagings) using general anesthesia technique

• American society of Anesthesiologists physical status grade I-II

• Capable to communicate in Thai language

Exclusion Criteria:

• Allergic to NSAIDs and opioid

• Allergic to Parecoxib drug

• Underlying neuropathic pain

• Pregnant woman or woman who undergoes breast feeding

• Uncontrolled hypertension disease, BP >160/110 at admission date

• Underlying ischemic heart disease, Ischemic stroke or peripheral arterial disease

• History status post coronary artery bypass grafting

• Patients who take Aspirin within 7 days before surgery date

• Had underlying which is contraindiated to NSAIDs drug such as Gastritis, history of GI ulcer, chronic kidney disease (Cr clearance < 30ml/min), liver cirrhosis (Child-Pugh class B or above/ serum albumin < 25 g/l)

• Patients who had NSAIDs drug while admit in hospital for preparing the operation before surgery date