Preemptive Paracetamol for Postoperative Pain

• Status: Unknown status
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test whether a dose of paracetamol given before surgical incision is more effective at reducing postoperative pain and analgesic consumption in cervical spine surgery versus a dose given at the end of surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Nottingham
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Aged 18-80 years old

• Patients listed for non-malignant cervical spinal surgery

• General anaesthesia

• Capacity to give informed consent

• Ability to use PCA device and pain score scale

• ASA I, II and III

• >50kg in weight

Exclusion Criteria:

• Allergy or sensitivity to paracetamol, proparacetamol or morphine

• Liver disease

• Renal disease (creatinine clearance <30ml/min)

• Bleeding disorder

• Chronic alcoholism

• Chronic malnutrition

• Dehydration

• G6PD deficiency

• Hypernatraemia (Na >150)

• Hypokalaemia (K <3.5) and hyperchloraemia

• Pregnancy or breast-feeding