Preemptive Resuscitation for Eradication of Septic Shock

• Status: Completed
• Trial end date: 2016-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the ability of an empiric resuscitation strategy compared to standard care to decrease the incidence of organ failure in normotensive sepsis patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Christiana Care Health Services

Criteria

Inclusion Criteria:

• Emergency department patient with suspected or confirmed infection as primary reason for admission

• Serum venous lactate 2.0 - 3.9 mmol/L

• Hospital admission planned

Exclusion Criteria:

• Age < 18 years

• Pregnancy

• Serum lactate ≥ 4.0 mmol/L

• Any vasopressor or inotrope requirement

• Mechanical ventilation or non-invasive positive pressure ventilation

• Chronic end-stage renal disease requiring hemodialysis

• Pulmonary edema as diagnosed by the primary care team

• Requirement for surgery within the treatment protocol timeframe

• Inability to obtain informed consent from subject or surrogate

• Patient to receive comfort measures only