Preemptive Tapentadol on Post-operative Analgesia Following Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2018-09-07
• Target enrollment: 0
• Participant gender: All

Summary

The study intends to evaluate the efficacy of Tapentadol against placebo as a preemptive analgesic in the management of post-operative pain in the patiens undergoing total knee arthroplasty.

The primary objective is to evaluate th epain score in visual analogue scale at various time points within 24 hours post operarively

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: All India Institute of Medical Sciences, Bhubaneswar
• Treatments: Tapentadol

Criteria

Inclusion Criteria:

• Patients of either sex undergoing elective tota knee replacement surgery

• Patients are capable to provide an informed consent

• Age 18-65 years

Exclusion Criteria:

• Patients with Asthma, copd or any other respiratory disease

• Persistent nausea , vomiting at the time of randomization

• Treated with MAO inhibitors, Tricyclic antidepressants, SSRIs and SNRIs

• Patients with ASA grading 3 or more

• Drug abuse history, opioid tolerance or dependence, known history of opiod allergies

• Renal or liver disease

• Major psychiatric disorder

• Pregnancy and lactation

• Emergency surgery

• Bone tumor, epilepsy or patients with migraine