Preemptive and Preventive Acetaminophen/Ibuprofen Fixed-dose Combination After Robot-assisted Radical Prostatectomy

• Status: Not yet recruiting
• Trial end date: 2023-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

This prospective, randomized, double-blinded study is designed to compare opioid-sparing effect of preemptive and preventive intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing robot-assisted radical prostatectomy (RARP). We hypothesize that preemptive administration of intravenous acetaminophen/ibuprofen fixed-dose combination can significantly reduce postoperative opioid consumption and pain severity than preventive administration in patients undergoing RARP.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Collaborator: Kyongbo Pharmaceutical
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• Patients scheduled to undergo elective robot-assisted radical prostatectomy under general anesthesia

• American Society of Anesthesiologists (ASA) physical classification I-II

• Consent to IV-patient controlled analgesia use

• Willingness and ability to sign an informed consent document

Exclusion Criteria:

• Who do not understand or agree with our study

• American Society of Anesthesiologists (ASA) physical classification III-IV

• Chronic usage of opioid analgesics

• Moderate to severe pain with other cause before surgery

• Allergies to anesthetic or analgesic medications used in this study

• Anticipated blood loss larger than 2 liters

• Need for intensive care after surgery

• History of gastric ulcer or gastrointestinal bleeding

• History of liver failure, renal failure or heart failure

• Current alcoholism

• Taking anti-coagulation drugs or history of coagulation disease

• History of bronchial asthma

• Medical or psychological disease that can affect the treatment response

• Taking barbitutate or tricyclic antidepressant