Pregabalin Reduce the Sevoflurane Requirement

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: Male

Summary

Preoperative administration of pregabalin would reduce the end tidal concentration of sevoflurane during laparoscopic cholecystectomy with added beneficial improving of the quality of postoperative analgesia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Pregabalin; Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists class I and II

• scheduled for elective laparoscopic cholecystectomy

• under sevoflurane anesthesia

Exclusion Criteria:

• communication barriers

• cardiovascular diseases

• renal diseases

• hepatic diseases

• endocrinal diseases

• neuropsychiatric diseases

• prolonged P-R interval

• pregnancy

• nursing

• hypersensitivity

• treated by pregabalin, antidepressant, anticonvulsants, opiates or benzodiazepines during the last week