Pregabalin Versus Celecoxib on Sevoflurane and Analgesic Consumption in Spine Fixation Surgery
Status:
Completed
Trial end date:
2020-02-01
Target enrollment:
Participant gender:
Summary
The anti-epileptic drugs such as gabapentin and other non-steroidal anti-inflammatory drugs
(NSAID) such as celecoxib were used as a part of multimodal analgesia to control such pain.
Gabapentin is an anticonvulsant drug that has analgesic effect in post-herpetic neuralgia,
diabetic neuropathy, and neuropathic pain. Celecoxib is one of the NSAIDs, that its analgesic
effect is reported in various studies by cyclooxygenase-2 (COX-2) inhibitor.
The aim of this randomized double-blinded study was to asses and compare the efficacy of
using gabapentin versus celecoxib as a part of multimodal analgesia in perioperative
hemodynamic control and pain relief in patients underwent posterior approach lumbar spine
disc fixation surgery.