Pregabalin Versus Gabapentin Opioid Sparing Effect in Discectomy

• Status: Enrolling by invitation
• Trial end date: 2022-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Pregabalin and gabapentin are both GABA analogue and their mechanism of action is not fully understood. Both drugs when given as a pre-emptive analgesia for spinal surgery were found to reduce intra-and postoperative opioid requirements.

Preoperative intramuscular injection of morphine could reduce the patients' pain during the percutaneous transformational endoscopic discectomy "PTED" surgery and improve the patients' satisfaction without affecting the surgical outcome. The efficacy of adding pregabalin or gabapentin to preoperative intramuscular morphine is not yet investigated.

The current study aims to compare the analgesic effect of both drugs when given preoperatively with intramuscular morphine.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Research Institute of Ophthalmology, Egypt
• Treatments: Gabapentin; Pregabalin; Vitamin B 12

Criteria

Inclusion Criteria:

• ASA I and ASA II

• Elective Lumber micro discectomy.

• BMI ≤ 35

• Time of operation not exceeding 2hours.

Exclusion Criteria:

• Patients' refusal

• Age < 20 years or > 60 years

• ASA III to ASA IV

• Contraindications to Opioids e.g., Allergy, Bronchial asthma.

• Contraindication to Pregabalin or Gabapentin e.g. Allergy

• Psychological or mental disorders.

• Disturbance of Conscious level.

• Uncooperative patients.

• Patients with impaired renal function or creatinine clearance less than 50ml/min