Pregabalin and Remifentanil - Analgesia and Ventilation

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

In this experimental study on healthy volunteers we explored the effect of pregabalin alone and in combination with remifentanil on acute experimental pain and ventilatory function.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Oslo University Hospital
• Treatments: Pregabalin; Remifentanil

Criteria

Inclusion Criteria:

• Healthy volunteers,

• > 18 yrs < 55 yrs,

• negative pregnancy test

Exclusion Criteria:

• Pregnancy,

• nursing,

• known heart-, lung- or liver disease,

• kidney failure/peptic ulcers,

• use of liver enzyme-inducing medications,

• known allergy against the medications used in the trial,

• use of psychotropic drugs, analgesics or alcohol used the last 24 hours before the trial,

• body weight > 100 kg or 30% deviation from normal weight,

• participant in other studies during the last 2 months,

• individuals who do not master Norwegian language