Pregabalin in the Prevention of Postoperative Delirium and Pain

• Status: Completed
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves overall pain control.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ottawa Hospital Research Institute
• Collaborator: Pfizer
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

• aged 60 years and older

• booked for major orthopaedic or vascular procedure

• expected length of stay > 2 days

Exclusion Criteria:

• open AAA repair

• EVAR

• allergy/sensitivity to pregabalin or gabapentin

• use of pregabalin or gabapentin in previous 14 days

• severe liver disease

• severe renal dysfunction defined as either having creatinine clearance < 30 ml/min or being dialysis-dependent

• seizure disorder

• MMSE < 24/30

• inability to speak English or French