Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel Syndrome
Status:
Completed
Trial end date:
2013-02-01
Target enrollment:
Participant gender:
Summary
The general aim of the current study is to describe the effect of pregabalin on colonic and
sensory functions in adults with constipation predominant irritable bowel syndrome (IBS-C).
Study hypotheses:
1. Single-dose pregabalin 200mg increases sensation thresholds and decreases sensation
ratings in response to balloon distension in the colon relative to pre-pregabalin
treatment.
2. Single-dose pregabalin 200 mg will increase colonic compliance and decrease colonic pain
and gas thresholds in patients with irritable bowel syndrome constipation predominant.
3. Single-dose pregabalin 200mg increases the colonic phasic and tonic response to a
standardized meal.