Pregabalin on Interleukin-6 Levels in Living Donor Kidney

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Pregabalin, a ligand for alfa2delta subunits of voltage-gated calcium channels, has been shown to be an effective adjuvant therapy for acute postoperative pain, by inhibiting central sensitization. The IL-6, is detectable 60 minutes after surgical incision, persisting for until 10 days, with maximal plasmatic level in 4 and 6 hours. The objective of this study is evaluating the analgesic effect of pregabalin and its repercussion on serum levels of IL6.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of São Paulo
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

• living donor kidney

Exclusion Criteria:

• myocardial ischemia

• psychiatric disease

• absence of chronic pain

• absence of drugs dependency

• don´t use of opioid medication 1 week before surgery