Premature Rupture of Membranes With a Bishop Score<6: Comparison of Medical Induction/Expectant Management

• Status: Recruiting
• Trial end date: 2022-03-30
• Target enrollment: 0
• Participant gender: Female

Summary

The study is intended to compare expectant management and on presentation labor induction in women with premature rupture of membranes.

The means of labor induction and cervical ripening are either oxytocin or dinoprostone.

Expectant management in this obstetrical state means waiting 24 hours from the onset of rupture of membranes and then commencing labor induction with either oxytocin or dinoprostone depending on the patient's obstetrical history and cervical condition.

The investigators' hypothesis is that active management will lead to a higher rate of vaginal deliveries, a shorter interval between the time of rupture of membranes and the time of delivery, a lower rate of cesarean sections and a better obstetric result for the mother and the fetus/newborn.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Dinoprostone; Oxytocin

Criteria

Inclusion Criteria:

• Term pregnancies >37 weeks of gestation.

• Certain rupture of membranes.

• Bishop score < 6.

• Singleton pregnancies.

• Vertex presentation.

• No obstetric or clinical contraindications for labor induction.

• Reactive non stress test on presentation.

Exclusion Criteria:

• Previous cesarean section.

• Previous uterine surgeries (Myomectomy etc.).

• Placenta Previa.

• Multiple gestation pregnancies.

• Pregnancies with history of fetal reduction or Intrapartum uterine fetal demise.

• Known fetal defects/Chromosomal abnormalities.

• Active genital Herpes.

• HIV carrier.

• Contractions that are less than 10 minutes apart.