Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
Background: Benzodiazepine, a common premedicant, suppresses endogenous melatonin levels and
thus paradoxically increases episodes of arousal during sleep and thus causes restlessness
and hangs over effects. Adding melatonin to it may decrease nocturnal arousal and promote the
perception of sound sleep in the perioperative period.
Methods: Eighty patients (ASA 1&2) with anxiety VAS ≥ 2 posted for general anaesthesia will
be randomly assigned to receive 0.5 mg alprazolam (Group A), 3 mg melatonin, a combination of
0.5 mg alprazolam and 3 mg melatonin (Group AM), or a similar looking placebo (Group P),
approximately 90 minutes before surgery.