Preop Dexmedetomidine Attenuates Haemodynamic Responses to Hydrodissection

• Status: Completed
• Trial end date: 2012-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Percutaneous tunnelling (hydrodissection) in the neck and anterior chest in patients undergoing robotic thyroidectomy leads to significant haemodynamic responses such as increases in blood pressure and heart rate. The investigators evaluated whether a single preoperative dexmedetomidine injection attenuated the haemodynamic responses to hydrodissection by reducing the half-maximal effective concentration (EC50) of remifentanil needed to maintain haemodynamic stability during hydrodissection.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Dexmedetomidine; Propofol; Remifentanil

Criteria

Inclusion Criteria:

• ASA physical status I-II patientsscheduled for general anaesthesia for robotic thyroidectomy

Exclusion Criteria:

• Patients with an allergy to α2-adrenergic agonists or propofol

• Patients with current antihypertensive medication

• Patients with heart block > 1 degree

• Patients with severe cardiorespiratory dysfunction

• Patients with history of alcohol or drug abuse

• Patients who had received an opioid analgesic medication within the previous 24-h period before the operation