Preoperative Anxiolysis With Intravenous Midazolam on Intraoperative Sevoflurane Gas Consumption
Status:
Not yet recruiting
Trial end date:
2022-09-20
Target enrollment:
Participant gender:
Summary
This prospective, randomized, double-blind, placebo-controlled study is performed after
obtaining written informed consent of patients who are scheduled for elective general
surgery. After the admission to the preoperative unit 30 minutes before the surgery, The
preoperative anxiety of patients is evaluated by The State-Trait Anxiety Inventory (STAI).
Patients are randomly assigned to one of two groups in a 1:1 ratio by a computer-generated
list. Patients receive midazolam IV at 0.04 mg/kg (group M) and an equal volume of saline IV
(group C, control group). Anesthesia is induced with 2mg/kg of IV propofol. At a dose of 0.6
mg/kg, IV rocuronium bromide is given for neuromuscular blockade. Anesthesia is maintained at
2% sevoflurane. At the end of the surgery, anesthesia is terminated and the awake patients
are extubated.