Preoperative Bevacizumab Injection in Primary Pterygium in Tunisian Patients
Status:
Completed
Trial end date:
2021-01-01
Target enrollment:
Participant gender:
Summary
Purpose: To assess the efficacy and safety of a single preoperative intra-lesional
bevacizumab injection in primary pterygium.
Methods: The investigators conducted a randomized controlled interventional study from
January 2019 to December 2020. The study included a total of 60 patients (60 eyes) with
primary pterygium. The investigators defined two groups of 30 patients each. Group A received
an intralesional injection of bevacizumab (Avastin), one month before surgery (lesion
excision and conjunctival autograft). Group B (control) had only the surgical treatment.
Patients were followed up seven days (D7), one month (M1), three months (M3), and six months
(M6) post-operatively. Pre-, per- and post-operatively, photographs of the lesions were
taken, as well as a pathological examination. The main outcome measures were the change in
functional discomfort following intralesional bevacizumab injection and pterygium recurrence.
Recurrence was defined by fibrovascular tissue growth extending more than 1 mm across the
limbus. Therapeutic success was defined as the absence of pterygium recurrence in M6.