Preoperative Chemoradiation Followed by Chemotherapy for Locally Advanced Rectal Cancer
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
The current standard treatment of locally advanced rectal cancer (clinical stage II or III)
is preoperative radiation with chemotherapy (CRT) followed by surgery. But this approach can
be suboptimal for patients with high risk features (more deeply-seated tumor or many regional
lymph nodes involved)that are associated with recurrence. This study test a hypothesis that
CRT followed by chemotherapy before surgery can improve efficacy of preoperative treatment.