Preoperative Cisplatin and Bevacizumab in ER-, PR-, HER2 Negative Breast Cancer

• Status: Completed
• Trial end date: 2020-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to find out what effect taking cisplatin in combination with bevacizumab before surgery and then standard chemotherapy plus bevacizumab after surgery will have on participants with Estrogen Receptor (ER) negative, Progesterone Receptor (PR) negative and Human Epidermal Growth Factor Receptor 2 (HER2) negative breast cancer. Cisplatin is used to destroy cancer cells in many types of cancers, and has shown to be effective and have manageable side effects. Bevacizumab is an antibody, which is a protein that attacks a foreign substance in the body. Bevacizumab slows or stops cell growth in cancerous tumors by decreasing the blood supply to the tumors.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborators: Beth Israel Deaconess Medical Center; Brigham and Women's Hospital; Dana-Farber Cancer Institute; Genentech, Inc.
• Treatments: Albumin-Bound Paclitaxel; Bevacizumab; Cisplatin; Cyclophosphamide; Doxorubicin; Paclitaxel

Criteria

Inclusion Criteria:

• All tumors must be ER-, PR- and HER2-negative

• Clinical stage T2 or T3, N0-3, M0. Subjects with inflammatory breast cancer are not eligible

• For subjects with clinically negative axilla, a sentinel lymph node biopsy will be performed either up front or after preoperative therapy at the discretion of the subject's physicians; for subjects with a clinically positive axilla, a needle aspiration or core biopsy will be performed to confirm the presence of metastatic disease in the lymph nodes.

• 18 years of age or older

• Performance status (PS) of 0 or 1

• Use of an effective means of contraception in subjects of child-bearing potential

• Normal organ function as described in the protocol

Exclusion Criteria:

• Any prior cytotoxic chemotherapy or radiation for the current breast cancer

• HER2-negative ipsilateral breast recurrence, unless prior treatment consisted of excision alone for ductal carcinoma in situ (DCIS)or breast-conserving treatment and hormonal therapy for DCIS or invasive cancer

• Life expectancy of less than 12 weeks

• Current, recent, or planned participation in an experimental durg study other than a Genentech-sponsored bevacizumab cancer study

• Renal dysfunction for which exposure to cisplatin would require dose modifications

• Steroid dependent asthma

• Peripheral neuropathy of any etiology that exceeds grade 1

• Uncontrolled diabetes

• History of malignancy treated without curative intent

• Any other pre-existing medical condition that would represent toxicity in excess of grade 1

• Inadequately controlled hypertension

• Any prior history of hypertensive crisis or hypertensive encephalopathy

• New York Heart Association (NYHA) Grade II or greater congestive hear failure

• History of myocardial infarction or unstable angina within 12 months prior to study enrollment

• Any history of stroke or transient ischemic attack at any time

• Known central nervous system (CNS) disease

• Significant vascular disease

• Symptomatic peripheral vascular disease

• Evidence of bleeding diathesis or coagulopathy

• Major surgical procedure, open biopsy, or significant traumatic injury within 21 days prior to study enrollment

• History of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months prior to study enrollment

• Serious, non-healing wound, ulcer or bone fracture

• Proteinuria at screening

• Known hypersensitivity to any component of bevacizumab

• Pregnant or lactating