Preoperative Gabapentin Versus Bisoprolol for Hemodynamic Optimization During Sinus Surgery

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

the current study hypothesized that Gabapentin can be effective as Bisoprolol in reduction of intraoperative bleeding, improving the operative's field visibility and increase the surgeon satisfaction via optimization of blood pressure and heart rate .

A prospective randomized double blinded controlled study. Eligible patients were randomized according to random list generated software and allocated into 3 equal and matched groups (15 patients in each group):-

• Group G: gabapentin group in which Patients were premedicated with oral gabapentin 1200 mg (Conventin 400mg; Evapharm) with sips of water, 2 hours before induction of anesthesia.

• Group B: bisoprolol group in which Patients were premedicated with oral bisoprolol 2.5 mg ( Concor 2.5mg ; Merck/Amoun ) with sips of water, 2 hours before induction of anesthesia.

• Group C: control group in which Patients were premedicated with oral placebo with sips of water, 2 hours before induction of anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zagazig University
• Treatments: Bisoprolol; Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• patients who underwent functional endoscopic sinus surgery

• ability to swallow tablets

Exclusion Criteria:

• suspected difficult airway

• basal HR <60/min.

• chronic cardiovascular or cerebrovascular disease

• bronchial asthma or COPD

• DM

• bleeding disorders

• anemia (Hb level< 10 gm/dl)

• renal or hepatic insufficiency

• psychiatric disorders

• chronic treatment by BBs, gabapentin or drugs that affect coagulation

• acute nasal infection

• allergy/contraindications to any of the study's drugs.