Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery

• Status: Active, not recruiting
• Trial end date: 2022-02-23
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption. Patients will receive either melatonin or a placebo for three nights prior to surgery and we will measure pre-operative anxiety, preoperative sleep quality, post op pain medication consumption, post op pain scores, and blood values.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Montefiore Medical Center
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• Subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction under IV sedation

• Ages 18-35

• ASA Class I or II

• English or Spanish speaking patients

• Capacity to sign informed consent

Exclusion Criteria:

• Allergies to melatonin, opioids, or other OTC pain medications

• Anyone currently taking melatonin for any reason

• Cases under local anesthesia

• ASA class III or higher

• Sleep disorder (insomnia/narcolepsy)

• Current or past history of substance abuse

• Chronic pain

• Language/communication barrier

• Psychiatric disease/ Mental impairment

• Current or past use of psychotropic drugs

• Pregnancy

• Renal or hepatic impairment

• BMI >35