Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy

• Status: Completed
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: All

Summary

To test whether 125 mg preoperative methylprednisolone intravenously can reduce postoperative pain after laparoscopy for suspected appendicitis and to test whether preoperative methylprednisolone can reduce postoperative fatigue, increase quality of sleep, reduce nausea or vomiting, reduce duration of convalescence and increase overall quality of recovery after laparoscopy for suspected appendicitis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jakob Kleif
• Collaborator: Zealand University Hospital
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Laparoscopy for suspected appendicitis

• Age 18 years or older

• American Society of Anesthesiologist (ASA) class I-III.

• Gives written and oral consent

Exclusion Criteria:

• Known inflammatory bowel disease.

• Known autoimmune disease.

• Chronic pain patient.

• Presumed poor compliance.

• Pregnant or breastfeeding.

• In systematic treatment with glucocorticoids or other immunosuppressive treatment.

• Known renal disease, GFR<30.

• Known liver cirrhosis.

• Known heart failure, EF<40%.

• Known glaucoma.

• Known ocular herpes simplex.

• Known cushings disease.