Overview
Preoperative Misoprostol in Reducing Blood Loss in Total Abdominal Hysterectomy (TAH)
Status:
Completed
Completed
Trial end date:
2008-04-01
2008-04-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
Total abdominal hysterectomy is known to be associated with operative blood loss, which can lead to patients' morbidity. Misoprostol, a prostaglandin, has been shown to be effective in reducing operative blood loss during myomectomy. It is the first study to investigate if preoperative misoprostol is effective in reducing operative blood loss during total abdominal hysterectomy.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
The University of Hong KongTreatments:
Misoprostol
Pyridoxal
Pyridoxine
Vitamin B 6
Vitamin B Complex
Vitamins
Criteria
Inclusion Criteria:- symptomatic women undergoing total abdominal hysterectomy for various benign
gynaecological diseases in Queen Mary Hospital
Exclusion Criteria:
- any contraindication to misoprostol, including mitral stenosis, glaucoma, sickle cell
anaemia, diastolic pressure over 100mmHg, severe asthma, or known allergy to
prostaglandin;
- a known history of pelvic/ovarian endometriosis;
- a known history of or active medical disease;
- a known history of previous myomectomy;
- women who had pre-operative mifepristone or gonadotrophin releasing hormone analogues
treatment;
- women with mental impairment or incompetent in giving consent.