Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to see if pre-operative regional nerve blocks compared to a placebo nerve block can decrease chronic post mastectomy pain, immediate postoperative pain and postoperative narcotic consumption.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Anesthetics; Bupivacaine

Criteria

Inclusion Criteria:

1. Women at least 19 years old who are able to provide written and informed consent

2. Women undergoing unilateral or bilateral, simple, skin-sparing, or nipple sparing mastectomy for breast cancer (Stage 0-III) or breast cancer prevention

3. Patients with ASA class of I-III will be included

Exclusion Criteria:

1. Stage IV breast cancer, morbid obesity with BMI >45kg/m2

2. Renal insufficiency (Creatinine >1.5 mg/dL)

3. Current chronic analgesic use (daily use for > or equal to 4 weeks)

4. History of opioid abuse or dependence

5. Presence of chronic pain with a self-reported average pain score of 4 or greater on a pain scale of 0-10 prior to any surgical intervention

6. Incarceration

7. Pregnancy

8. Immediate autologous tissue reconstruction.