Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer
Status:
Recruiting
Trial end date:
2029-12-31
Target enrollment:
Participant gender:
Summary
The treatment protocol proposed in this study is to perform short-term radiation therapy and
4 cycles of FOLFOX chemotherapy for neoadjuvant treatment of locally advanced rectal cancer.
Compared to conventional chemoradiation therapy, the preoperative radiotherapy period is
shortened, and the cure rate of rectal cancer patients can be improved by early treatment of
micrometastasis using systemic chemotherapy. The patients who are assigned to the study group
will received the short-course radiotherapy and 4 cycles of FOLFOX and patients in the
control will received conventional chemoradiotherapy for preoperative treatment. All patients
are recommended to receive total mesorectal excision (TME) after neoadjuvant treatment and
adjuvant chemotherapy will be given according to the pathological stage.