Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients
Status:
Terminated
Trial end date:
2021-07-29
Target enrollment:
Participant gender:
Summary
This study will recruit patients more than 65 years old eligible for non-cardiac surgery.
Patients who participate will take either vitamin B12 and folic acid supplementation or
placebo for 7 days before surgery. Neuropsychological test battery (NPB) will be tested
before intervention and at discharge for determination of Post operative cognitive
dysfunction (POCD). Another group of non-surgical elderly participants will also be tested
for NPB to account for learning effect in POCD diagnosis. The hypothesis is that preoperative
vitamin B12 supplementation will reduce the incidence of POCD in elderly patients undergoing
non-cardiac surgery.
Phase:
N/A
Details
Lead Sponsor:
Xijing Hospital
Collaborators:
Anhui Provincial Hospital First Affiliated Hospital Xi'an Jiaotong University Shaanxi Provincial People's Hospital Shanghai 10th People's Hospital Tang-Du Hospital The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Treatments:
Folic Acid Hydroxocobalamin Vitamin B 12 Vitamin B Complex Vitamins