Preoperative vs. Postoperative Rectal Misoprostol in Cesarean Section

• Status: Completed
• Trial end date: 2018-03-20
• Target enrollment: 0
• Participant gender: Female

Summary

This prospective double-blind placebo-controlled randomized clinical trial will be conducted at Ain-Shams University Maternity Hospital from April 2017 till December 2017. Group 1 women, candidates for cesarean section, will receive preoperative rectal 400 microgram of misoprostol, and Group 2 women will receive postoperative rectal 400 microgram of misoprostol.

2017. 120 women candidate foe elective cesarean section will receive preoperative sublingual 400 microgram of misoprostol, and another 120 women will receive postoperative sublingual 400 microgram of misoprostol.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Misoprostol

Criteria

Inclusion Criteria:

1. Patients candidate for cesarean section.

2. Full term pregnancies (GA 37- 42 Wks).

3. Age (18-40 yrs).

4. body mass index (BMI) (20-30(Kg/m2 .

Exclusion Criteia:

1. Contraindication to spinal anesthesia.

2. Blood dyscrasias.

3. Large fibroids.

4. Contraindications to prostaglandin therapy (e.g. history of severe bronchial asthma or allergy to misoprostol.

5. Emergency CS such as fetal distress

6. Extreme of BMI (<20 or >30 Kg/m2 ).