Preparation and Characterization Intranasal Film Loaded With Steroid as a Local Treatment of Anosmia in Compare to Insulin Intranasal Film

• Status: Recruiting
• Trial end date: 2023-05-20
• Target enrollment: 0
• Participant gender: All

Summary

This study is a growing step of phase I study published on March 2021. The study was implicated on Minia university on small scale of patient (20) to investigate the impact of insulin as fast dissolving films for intranasal delivery to treat anosmia in post COVID-19 infections. this record will modify the first formulation by addition certain concentration of steroid.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Deraya University
• Treatments: Prednisolone

Criteria

Inclusion Criteria:

• All patients' adults aged from 18 years to 50 will included in the study.

• A confirmed case (positive PCR), recovered/discharged (2 negative PCR),

• suffering from sudden recent anosmia or hyposmia with or without loss of taste.

Exclusion Criteria:

1. Patients with chronic sinusitis.

2. Patients with acute allergic rhinitis.

3. Patients' nasal polyposis

4. Patients with history of nasal surgery, severe head trauma or any medical condition that may affect sense of smell.

5. Patient poly morbidities or poly pharmacy.

6. Elder, pregnant, or nursing woman.

7. Patients with chronic diseases.

8. Autoimmune diseases.

9. Patient suffering end organ problems.