Preterm Neonates Brain Ultrasound With CEUS and Elastography

• Status: Not yet recruiting
• Trial end date: 2029-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to investigate levels of brain perfusion and elasticity in preterm neonates when they reach the estimated due date and to compare the data with magnetic resonance imaging at term. Contrast enhanced ultrasound (sulphur hexafluoride) and ultrasound-assisted elastography will be used to evaluate the state of brain perfusion with ultrasound. Different appropriate imaging sequences will be used regarding MRI, including asl-perfusion. Neonates recruited from the Neonatal Intensive Care Unit (NICU) of Turku University Hospital will be recruited.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Turku University Hospital

Criteria

Inclusion Criteria:

• Preterm neonates attending brain MR-imaging at term

Exclusion Criteria:

• Pre-known genetic disease

• Difficult congenital malformations that need surgical treatment

• Central nervous system tumors

• Weight less than 2,5 kg during examination

• Medical history of SonoVue hypersensitivity

• Uncontrolled systemic hypertension

• Systolic pulmonary artery pressure > 90 mmHg

• Unstable cardiovascular state