Pretreatment With Unfractionated Heparin for ST Elevation Myocardial Infarction

• Status: Not yet recruiting
• Trial end date: 2023-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Rupture of a coronary artery plaque leads to thrombotic occlusion of the coronary artery and would present as ST segment elevation myocardial infarction. Early treatment with aspirin and early primary percutaneous coronary intervention are indicated. Anticoagulation therapy, usually with unfractionated heparin, is required during percutaneous coronary intervention.

Investigators hypothesis is that pretreatment with unfractionated heparin in addition to aspirin at first medical contact may facilitate spontaneous reperfusion of culprit artery and procedural thrombotic complication in patients with ST elevation myocardial infarction without significant risk of bleeding complications.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Medical Centre Ljubljana
• Treatments: Calcium heparin; Heparin

Criteria

Inclusion Criteria:

• Adult patients with STEMI referred for primary PCI

• Duration of symptoms less than 6 hours before presentation

Exclusion Criteria:

• Pregnancy

• Cardiogenic shock at presentation (hemodynamic instability)

• Cardiac arrest before randomization

• Duration of symptoms for more than 6 hours before presentation