Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This research study is examining a preventive skin care regimen for children diagnosed with a brain tumor and receiving anti-cancer therapy with a MEK, Pan-RAF, or BRAF inhibitor.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dana-Farber Cancer Institute

Criteria

Inclusion Criteria:

• Diagnosed with a brain tumor between ages 6 months old -18 years old and will undergo treatment with at least one of the following:

1. Targeted BRAF inhibitor therapy to treat the brain tumor

2. Targeted MEK inhibitor therapy to treat the brain tumor

3. Targeted pan-RAF inhibitor therapy to treat the brain tumor

• Subjects may participate in other studies, including therapeutic trials.

• Ability to comply with PSCR including sun protection, gentle skin care and every other day dilute bleach baths.

• Ability to understand and/or the willingness of their parent or legally authorized representative to sign a written informed consent document.

Exclusion Criteria:

• Diagnosed with brain tumor at > 18 years old

• No data in medical records regarding treatment exposures

• Treated with a BRAF, MEK or pan-RAF inhibitor in the last three months

• Past or present allergic reaction to bleach

• Past or present allergic reactions to sunscreen and/or creams, lotions, emollients to be utilized in this study