Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation
Status:
Completed
Trial end date:
2021-06-21
Target enrollment:
Participant gender:
Summary
Complications are common during tracheal intubation of critically ill patients. Nearly one in
five patients undergoing intubation in the intensive care unit experiences cardiovascular
collapse, defined as severe hypotension, vasopressor administration, cardiac arrest or death.
Cardiovascular collapse during intubation is associated with increased resource utilization
and decreased survival. Administration of 500 mL of intravenous crystalloid solution
beginning prior to induction may prevent cardiovascular collapse. The only prior trial
examining fluid bolus administration during intubation found no effect on cardiovascular
collapse or clinical outcomes overall, but a hypothesis-generating subgroup analysis
suggested potential benefit to fluid bolus administration among patients receiving positive
pressure ventilation between induction and laryngoscopy. Therefore, we propose a randomized
trial comparing fluid bolus administration versus none with regard to cardiovascular collapse
among critically adults undergoing intubation with positive pressure ventilation between
induction and laryngoscopy.