Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Tracheal intubation (TI) is associated with a high risk of adverse events in critically ill
patients and peri-intubation hemodynamic collapse is the most commonly observed. The primary
aim of the PREVENTION trial is to compare the effect of the pre-emptive use of noradrenaline
versus no peri-intubation use of noradrenaline on incidence of cardiovascular collapse
following TI in adult critically ill patients. Patients with absolute indication or
contraindication to vasopressor support will be excluded from this trial. Patients will be
randomized 1:1 to a continuous infusion of noradrenaline started before induction titrated to
the goal of MAP 100 mmHg. The primary outcome will be the incidence of cardiovascular
collapse. Secondary outcomes will include lowest systolic blood pressure within 30 minutes,
ICU and in-hospital mortality.