Preventing Frequent Sinus Infections in HIV-Infected Patients
Status:
Withdrawn
Trial end date:
1993-02-01
Target enrollment:
Participant gender:
Summary
To evaluate the additional effectiveness of an anti-inflammatory nasal spray ( beclomethasone
dipropionate ) and a broad spectrum antibiotic ( cefuroxime axetil ) over decongestant (
Deconsal II ) alone, when these agents are given individually or in combination for the
prevention of recurrent paranasal sinus infection in patients with HIV infection. To compare
the clinical utility of paranasal sinus radiographs with computed tomograms (CTs) in the
evaluation and management of HIV-infected patients with recurrent paranasal sinus infection.
To determine relevant prognostic factors and the microbiologic etiology of maxillary
sinusitis in this patient population.
Sinusitis is common among HIV-infected patients and is likely to be recurrent or refractory
to traditional therapy, particularly in patients with advanced immunosuppression. An
intervention aimed at prevention of recurrent sinus disease in HIV-infected patients appears
to be warranted.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)