Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi
Status:
Not yet recruiting
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
This is an individually randomized, controlled, single blind four arm clinical trial of
malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with
dihydroartemisinin-piperaquine (IPT-DP). Arm 2: Intermittent preventive treatment with
sulfadoxine-pyrimethamine (SP) plus chloroquine (CQ) (IPT-SPCQ). Arm 3: Intermittent
preventive treatment with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) (IPT-SPAQ).Arm
4: Control - students will receive standard of care (no preventive treatment). Outcomes
include P. falciparum infection and parasite density, anemia, cognitive function and
educational testing, as well as infection prevalence and disease incidence in young children
sleeping student's households to assess the impact on transmission.