Preventing Pain After Heart Surgery

• Status: Unknown status
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The use of pre-emptive analgesia to prevent pain following sternotomy for cardiac surgery

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Barts & The London NHS Trust
• Treatments: Ketamine; Pregabalin

Criteria

Inclusion Criteria:

• Informed Consent

• First time sternotomy for all cardiac surgery

• Patient aged 18 - 80 years

Exclusion Criteria:

• Emergency surgery (decision to operate taken on the day of surgery)

• Previous sternotomy

• Preoperative renal failure (eGFR <60 ml/min)

• History of chronic non-anginal pain

• Chronic pain medication other than paracetamol and non-steroidal anti-inflammatory drugs

• Concurrent use of oxycodone, lorazepam, or ethanol.

• Concurrent use of any drugs for neuropathic pain e.g. antiepileptics, antidepressants

• Allergy to pregabalin, gabapentin or ketamine

• Pregnancy

• Limited understanding of numerical scoring scales

• Previous participation in other trials investigating analgesic agents or any IMP in previous three months