Preventing Propofol-associated Injection Pain

• Status: Completed
• Trial end date: 2009-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics have been shown to attenuate this response in some patients. This randomized, double-blind, placebo-controlled trial tests the hypothesis that lidocaine mixed with propofol will be superior to lidocaine administered directly into the vein, under tourniquet control, prior to injection of propofol. Both groups are expected to be superior to placebo.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Benaroya Research Institute
• Treatments: Lidocaine; Propofol

Criteria

Inclusion criteria:

• weight >40kg, <100kg

• ambulatory surgery

Exclusion criteria:

• allergy to propofol or lidocaine

• taking opioids, benzodiazepines, or nonsteroidal antiinflammatory drugs (NSAIDs)