Preventing Recurrent Urinary Tract Infections With α-D-mannose

• Status: Terminated
• Trial end date: 2020-05-31
• Target enrollment: 0
• Participant gender: Female

Summary

In this trial, women with history of recurrent urinary tract infections (UTIs) will be followed over the course of 6 months. The women will be randomized either to D- Mannose or Placebo.

The primary objective of this study is to investigate if treatment with D-mannose reduces the risk for a UTI recurrence compared to treatment with Placebo.

H0: Women with history of recurrent UTIs treated with D-Mannose on average have the same number of recurrent UTIs over the course of 6 months compared to women treated with Placebo.

H1: Women with history of recurrent UTIs treated with D-Mannose on average have fewer recurrent UTIs over the course of 6 months compared to women treated with Placebo.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kantonsspital Aarau

Criteria

Inclusion Criteria:

• Women

• ≥ 3 UTIs within the last 12 months or ≥ 2 UTIs within the last 6 months;

• Laboratory urine culture: <103 CFUs

• Age > 18 years

Exclusion Criteria:

• UTIs ≥ 12 within 1 year

• Pregnancy or Lactation

• Immune disease

• Lactose intolerance

• Urinary tract anomaly

• Systemic infection

• Newly started hormone therapy within the last 6 months

• Antibiotic prophylaxis within the last 6 months

• α-D-mannose intake within the last month

• Use of catheters

• Diabetes mellitus

• Participation to other studies