Preventing Urinary Tract Infections With E. Coli Nissle:

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Urinary tract infections (UTIs) account for 5-14% of pediatric emergency department visits annually. At the moment, up to one third of children suffering of acute (UTI) will have a new infection and there is a lack of effective methods for preventing secondary UTIs in young children. Majority of UTIs in children are caused by intestinal bacteria of the patient, mainly E. coli that colonizes gut of the patient. E. coli Nissle is a probiotic strain that has been used successfully for treating acute gastrointestinal infections in children. The strain has also been proved to be safe for infants and young children. E. coli Nissle could be a potential solution for preventing recurrent urinary tract infections in children as it competes with pathogenic bacteria that usually cause UTIs in children.

The aim of this study is to evaluate efficacy of E. coli Nissle strain in secondary prevention of urinary tract infections in young children.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Oulu
• Collaborators: Helsinki University Central Hospital; Kuopio University Hospital; Tampere University Hospital; Turku University Hospital

Criteria

Inclusion Criteria:

• Children who suffer of the first urinary tract infection of their life defined as pyuria, presence of symptoms (fever or focal symptom), no other explanation for infection, bacterial culture positive or culture result pending

• Written informed consent

Exclusion Criteria:

• Preterm birth, gestational age less than 35 weeks

• Signs of life-threatening infection (such as meningitis)

• Detected anomaly in urinary tract

• Primary immunodeficiency

• Detected anomaly of GE tract

• Ongoing antimicrobial prophylaxis

• Hospital-acquired infection