Preventing Weight Gain and Controlling Blood Pressure During Smoking Cessation in Hypertensive Smokers

• Status: Completed
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to develop effective interventions that assist individuals with high blood pressure to quit smoking and prevent weight gain.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Iowa
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Nicotine

Criteria

Inclusion Criteria:

• Smoke at least 5 cigarettes/day (or have quit within the last 6 weeks to enter the study for the weight gain prevention and BP control interventions)

• Pre-hypertensive or Stage I hypertension (systolic BP from 120 to 159 and/or diastolic BP from 80 to 99 mm Hg). Antihypertensive medications are not criteria for exclusion provided that BP is not over 160/100 mm Hg)

• Access to a telephone

Exclusion Criteria:

• History of unstable cardiovascular disease, including myocardial infarction, stroke, and unstable angina within three months of study start

• Coronary artery bypass grafting or angioplasty/stent within three months of study start

• Cardiac dysrhythmia treated with anti-arrhythmia medication, except stable atrial fibrillation

• Untreated hyperthyroidism or pheochromocytoma

• History of congestive heart failure (NYHA Class III or IV)

• ECG evidence of 2nd or 3rd degree atrioventricular block

• Uncontrolled or Stage II Hypertension as defined as BP consistently above 160/100 mm Hg

• History of severe liver or kidney failure

• Current substance abuse (includes alcohol use in excess of 21 drinks a week)

• Presence of an unstable psychiatric condition

• Severe chronic obstructive pulmonary disease

• Symptomatic peripheral vascular disease

• Pulmonary hypertension with shortness of breath

• Congenital or valvular heart disease with shortness of breath

• Current use of a medication that may interfere with primary study endpoints or that may increase the risk of side effects from study medication that cannot be discontinued

• Pregnant or plans to become pregnant within the next year

• Planning to move out of the area or travel extensively during the intervention

• Any medical condition that would preclude any additional changes in diet

• Unable to further modify physical activity routine

• Cannot engage in moderate intensity exercise (e.g., walking)