Preventing pAIn With NMDA Antagonists - Steroids in Thoracoscopic lObectomy Procedures (PAIN-STOP) Pilot Trial
Status:
Terminated
Trial end date:
2019-03-31
Target enrollment:
Participant gender:
Summary
The objective of the PAIN-STOP trial is to assess the feasibility of a larger randomized
controlled trial (RCT) evaluating NMDA antagonists and IV steroids, as compared to placebo,
in decreasing the chances of clinically significant persistent post-surgical pain (PPSP)
after video assisted thoracoscopic surgeries (VATS). This is a multi-centre randomized,
controlled clinical trial with a 2 x 2 factorial design. The pilot phase of the trial will
recruit 48 patients and follow them for 3 months. Patients will be randomized to one of four
groups: 1) NMDA active + Steroid placebo; 2) Steroid active + NMDA placebo; 3) NMDA active +
Steroid active; 4) NMDA placebo + Steroid placebo.