Prevention and Treatment of Reperfusion Injury After Mechanical Thrombectomy in Acute Ischemic Stroke
Status:
Not yet recruiting
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
Ischemic stroke accounts for 80% of all strokes and there is a lack of effective treatment
options.Mechanical thrombectomy can significantly improve the vascular recanalization rate
and reduce the disability rate of stroke, but the problem of reperfusion injury caused by
vascular recanalization is more prominent than before.
The most common manifestation of reperfusion injury is postoperative hemorrhage
transformation in the infarct area, which is caused by the inability of blood vessels to
tolerate normal perfusion pressure after endothelial cell injury.Therefore, in addition to
using necessary strategies to reduce the risk of bleeding before and during surgery,
maintaining an appropriate and individualized perfusion pressure after surgery is also an
important strategy to prevent and treat postoperative bleeding.
Lead a multicenter, randomized, controlled study looking at Individuation lowers blood
pressure.( Drop systolic blood pressure to 90-110mmHg，Blood pressure not lower than 90/60 mm
Hg，The reduced blood pressure was maintained for 48 hours). Influence of the incidence of
hemorrhage transformation caused by reperfusion injury after mechanical thrombectomy and
prognosis (modified Rankin Scale (mRS) score and proportion of patients with mRS≤2) at
48hours, 14 and 90 days after surgery.Thus, provide clinical evidence for blood pressure
management strategy after mechanical thrombectomy.