Prevention of Acute Kidney Injury in Cardiac Surgery Patients
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
Acute kidney injury (AKI) has no uniform criteria, but is commonly defined as an increase in
serum creatinine concentration by at least 25% from baseline. It occurs in 30% of patients
following cardiac surgery, and at least 50% of patients with underlying renal insufficiency.
Patients who have a reduced creatinine clearance pre-operatively are at the greatest risk of
developing post-operative AKI. The purpose of the current study is to determine if
intravenous hydration with either isotonic saline or sodium bicarbonate 150 mEq/L is
effective at preventing post-operative AKI in patients with baseline kidney insufficiency and
who are undergoing cardiac surgery using cardiopulmonary bypass. The study hypothesis is that
an infusion of sodium bicarbonate 150 mEq/L will be more effective than isotonic saline in
reducing the incidence of post-operative AKI in cardiac surgery patients with a preoperative
glomerular filtration rate (GFR) less than 60 ml/min/1.73m2.