Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS)

• Status: Completed
• Trial end date: 2010-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a research study on Altitude Illness. From the information collected and studied in this project we hope to learn more about Altitude Illness, including factors that may affect and prevent the development and progression of this condition. We hope to learn if the commonly used non-steroidal anti-inflammatory medication, ibuprofen can prevent altitude illness. Possible participants in this study are healthy adults who indicated they would like to participate, learn about altitude illness, and desire to hike Barcroft Peak. Stanford University researchers hope to enroll about 100 participants.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Stanford University
• Collaborator: University of California, San Diego
• Treatments: Anti-Inflammatory Agents; Ibuprofen

Criteria

Inclusion Criteria:

1. Healthy Male or female volunteer

2. Age 18-65

3. Sea-level dwelling

4. Non pregnant

5. Have not been to high altitude in the past week

6. Can arrange for their own transportation to WMRS by friday evening the weekend of their study enrollment and are available the duration of the weekend of their study enrollment

Exclusion Criteria:

1. Age <18 or >65

2. Live at altitude > Sea Level +/- 1000'

3. Pregnant

4. Taking NSAIDs, Acetazolamide, or Corticosteroids

5. Allergic to NSAIDs or Aspirin, or have had adverse reaction to them in the past

6. Traveled or planning to travel to high altitude in the week prior to their enrollment.

7. Medical history of Brain Tumor, increased intercranial pressure, pseudotumor cerebri, ventricular shunts, loss of an eye, Asthma, HACE or HAPE.

8. Cannot arrange for their own transportation to WMRS or are unavailable for the duration of the weekend of their study enrollment