Prevention of Atrial Fibrillation Following Esophagectomy

• Status: Completed
• Trial end date: 2008-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following esophagectomy surgery. Their specific aims are to:

Determine the effectiveness of amiodarone for the prevention of AF following esophagectomy surgery; Determine the influence of the prevention of AF following esophagectomy surgery on post-surgical duration of stay in the Intensive Care Unit ICU)and duration of post-surgical hospital stay; and Determine the safety of amiodarone for the prevention of AF following esophagectomy surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indiana University
• Collaborators: Indiana University Health; Purdue University
• Treatments: Amiodarone

Criteria

Inclusion Criteria:

• Males or females over the age of 40

• Scheduled to undergo esophagectomy

Exclusion Criteria:

• History of atrial fibrillation

• Prior severe side effects from amiodarone

• Elevated liver enzymes >3 times the upper limit of normal (UNL)

• Corrected QT interval > 450 ms

• Receiving class Ia or class III antiarrhythmics